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Professor HOR TZI SUM, ANDY

D.Sc., 1999, University of London; D.Phil., 1983, Oxford University; B.Sc.(Hons), 1979, Imperial College (London). Postdoctorate Associate, Yale University.

Contact Information
Department of Chemistry, NUS 3 Science Drive 3 Singapore 117543	Office: S8-03-15/S9-05-06 Tel/Fax: (65) 6516-2658/2663 Email: andyhor@nus.edu.sg

We welcome applications to join our group as Ph.D. students. The Department provides graduate scholarship support. Refer to here for more information. We also provide scholarship support from our grants.

Research Interests

Organometallic Materials and Catalysis

We are interested in a range of scientific challenges and technological problems. Some of them are given belows:

a) Metallocenyl Catalysis

We are developing a range of highly unsaturated metallocene-functionalized complexes that are catalytically active in C-C coupling reactions. We extend the scientific spectrum from ligand design, through complex syntheses, to catalytic investigations and mechanistic explanation.

b) Bioorganometallic Chemistry

We use rhenium complexes as models to study radiolabelling, imaging, therapeutic and other biomedical applications. Recently, we have developed a range of [Re(CO)]₃chelates for possible use as therapeutic radiopharmaceuticals, especially in the area of hepatocellular carcinoma. The interaction between these Re agents and lipiodol are being studied

c) Solution Metallo-Metallo and Metallo-Organic Interactions Under Ambient & Pressurized Conditions

Much of the current development of the {Pt₂S₂} and {Pt₂Se₂} chemistry are rooted to our long-standing effort in this area. In recent years, we have extended from the original structure-based investigations to metal-mediated synthesis, electrochemical exploration, and ESMS-inspired combinatorial-type syntheses. The rich chemistry revealed insofar has prompted us to extend the boundary to study intermolecular interactions under ambient as well as pressurized conditions. The enhanced intermolecular interaction in bimolecular reactions could yield new products hitherto unknown, or to suppress unimolecular-type decomposition that would have otherwise taken place. This project aims to expand the current synthetic technology to unorthodox means in an attempt to create new products that are medically and/or technologically significant. Our recent attempt in the synthesis of organosulfur is one of such examples.

d) ESMS-Directed Heterometallic Syntheses

We have developed Fenn's ESMS technique to a combichem-type methodology that facilitates parallel chemical syntheses and in situ monitor of reactions. We are currently studying a range of other molecular systems.

e) Supramolecular Assembly

A number of metals, spacers and other functionalites are being explored, with an intention to understand (and hopefully control) the intermolecular forces and shape the supramolecular assembly. Parallel to this, we are also developing molecular geometries that are structurally distinctive. A typical example is a molecular square recently identified in our laboratory

Recent Publications

J S L Yeo, J J Vittal and T S A Hor, Facile metal - mediated synthesis of macrocyclic diselenoethers, Eur. J. Inorg. Chem., 2003, 277-280.

Y Liu, S W Chien, S B Koh, T S A Hor and J J Vittal, Bimetallic complexes supported by bis(diphenylphosphino) methane anti and syn to the m-Pd bonds, Inorg. Chim. Acta, 2003, 350, 86-92.

F Chen, G Q Xu and T S A Hor, Preparation and assembly of colloidal gold nanoparticles in CTAB-stabilized reverse microemulsion, Mater. Lett., 2003, 57, 3282-32836.

S W A Fong, T S A Hor, W Henderson, B K Nicholson, S Gardyne and S M Devoy, Coodinartion chemistry of the [Pt₂(m-S)₂(PPh₃)₄] metalloligand with π-hydrocarbon derivatives of d⁶ ruthenium(II), osmium(II), rhodium(III) and iridium(III), J. Organomet. Chem., 2003, 679, 24-31.

S H Chong and T S A Hor, Electrospray Mass Spectrometric Investigation of the Reactivity of the Sulfide centers in [Pt₂(-S)₂(PPh₃)₄] Towards Organic Dihalides and the Catalytic Potential of this complex in the Syntheses of Organosulfur materials, Journal of Molecular Catalysis A: Chemical, 2003, 204-205, 267-277.

Z Li, K F Mok and T S A Hor, Heterometallic multinuclear Pt-M (M = Au, Ag) structural assemblies from dinulear [Pt₂(P-P)₂(-S)₂] (P-P = 2PPh₃, dppf), J. Organomet. Chem., 2003, 682, 73-78.

P Teo, L L Koh and T S A Hor, Unusual coordination assemblies from platinum(II) thienyl and bithienyl complexes, Inorg. Chem., 2003, 42, 7290-7296.

X Lu, S Y Ng, J J Vittal G K Tan, L Y Goh and T S A Hor, Structural dynamics and ligand mobility in carboxylate and dithiocarbamate complexes of Ru(II) containing 1,1'-bis(diphenylphopsphino)ferrocene (dppf), J. Organomet. Chem., 2003, 688, 100-111.

Z Li, W. Zheng, H. Liu, K F Mok and T S A Hor, Interpolymetallic assembly of d⁸-d¹⁰ sulfide aggregares from [Pt₂(PPh₃)₄(m-S)₂] and group 12 metals, Inorg. Chem., 2003, 42, 8481-8488.

Z Weng, L L Koh and T S A Hor, Suzuki cross-coupling in aqueous media catalyzed by a 1,1'-N-substituted ferrocenediyl Pd(II) complex, J. Organomet. Chem., 2003, 689, 18-24.

S W A Fong, T S A Hor, S M Devoy, B A Waugh, B K Nicholson and W Henderson, An electrospray mass spectrometry-directed survey of the coordination chemistry of the metalloligand [Pt₂(m-S)₂(PPh₃)₄] with platinum(II) and palladium(II) chloride substrates: influence of metal-ligand lability on product type, Inorg. Chim. Acta, 2003, 357, 2081-2090.

S W A Fong, T S A Hor, J J Vittal, W Henderson and S Cramp, Coordination chemistry of the metalloligand [Pt₂(m-S)₂(PPh₃)₄] with nickel(II) complexes - an electrospray mass spectrometry directed synthetic study, Inorg. Chim. Acta, 2003, 357, 1152-1160.

F Zhao, X Xu, S B khoo, J J Vittal and T S A Hor, Structure-dependent electrochemical behaviors in N,N-heterocyclic thienyl platinum(II) mono- and di-nuclear systems, Eur. J. Inorg. Chem., 2004, 69-77.

X L Lu, J J Vittal, E R T Tiekink, L Y Goh and T S A Hor, Chloride substitution of [CpRu(dppf)Cl] with sulfur-containing ligands, J. Organomet. Chem., 2004, 689, 1444-1451.

X L Lu, J J Vittal, E R T Tiekink, G K Tan, S L Kuan, L Y Goh and T S Andy Hor, Comparative reactivity studies of dppf-containing CpRu^II and (C₆Me₆)RuII complexes towards different donor ligands (dppf = 1,1'-bis(diphenylphospino)ferrocene), J. Organomet. Chem., 2004, 689, 1978-1990.

X L Lu, W K Leong, L Y Goh and T S A Hor, Supramolecular structures in [Ag(dppf)] complexes [dppf = 1,1'-bis(diphenylphosphino ferrocene)] stabilized by coordinatively versatile trifluoroacetate ligands (TFA), Eur. J. Inorg. Chem., 2004, 2504-2513.

X L Lu, W K Leong, T S A Hor and L Y Goh, Coordination polymers and supramolecular structures in Ag(I)triflate-dppf systems [dppf = 1,1' bis(diphenylphosphino ferrocene)], J. Organomet. Chem., 2004, 689, 1746-1756.

H H Huynh, D L Van, F E Hahn and T S A Hor, Synthesis and structural characterization of mixed carbine-carboxylate complexes of palladium(II), J. Organomet. Chem., 2004, 689, 1766-1770.

Z Weng, S Teo, L L Koh and T S A Hor, Crystallographic characterization of a Pd(II) metallamacrocycle supported by an amino-functionalized ferrocene and its use as an efficient Suzuki-coupling catalyst, Organometallics, 2004, 23, 3603-3609.

K E Neo, S W Chien, Y C Neo, G K Tan, A L Wilkins, W Henderson and T S A Hor, Use of cyclometallated PdCl(PPh₂CH₂CH₂CHCH₂CH₂PPh₂) as a precursor to homo and heterometallic species directed by Electrospray Ionisation Mass Spectrometry (ESMS), J. Chem. Soc. Dalton Trans., 2004, 2281-2287.

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