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Professor LI FONG YAU, SAM
B.Sc., 1981, Imperial College; Ph.D., 1984, Imperial College; D.Sc., 1999, University of London
Contact Information
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Department of Chemistry, NUS
3 Science Drive 3
Singapore 117543
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Office: S5-02-03
Tel: (65)-6516-2681
Fax: (65)-6779-1691
Email: chmlifys@nus.edu.sg |
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Research Interests
Analytical Chemistry
 Capillary electrophoresis and chromatographic techniques: New analytical methods based on capillary electrophoresis have been developed. The methods have been applied in environmental, pharmaceutical, biochemical and clinical analyses. Supercritical fluid extraction has been used to extract compounds from natural products and environmental samples. Methods have been developed for systematic optimization of high performance liquid chromatographic separations.
Atomic force microscopy and related scanning probe techniques: Nanoscale analysis and device fabrication by scanning probe techniques have been studied. On-going research projects include development of in-situ monitoring techniques for semiconductor manufacturing processes by atomic force microscopy, and study of lubricants on hard disk by atomic force microscopy and frictional force microscopy.
Sensor technology: Quartz Crystal microbalance and surface acoustic wave devices are used for chemical sensing, biosensing, process control and environmental monitoring. Selective coatings are developed for detection of various chemicals and biochemicals, such as toxic vapors, environmental pollutants in water samples, proteins and antigens.
Representative Publications
A. P. Fang, H. Ng, X. D. Su and S. F. Y. Li. Soft-Lithography-Mediated Submicrometer Patterning of Self-Assembled Monolayer of Hemoglobin on ITO Surfaces. Langmuir, 16, 5221-5226 (2000).
Y. S. Wu, H. K. Lee and S. F. Y. Li. Simultaneous Chiral Separation of Triadimefon and Triadimenol by Sulfated b-Cyclodextrin-Mediated Capillary Electrophoresis. Electrophoresis, 21, 1611-1619 (2000).
Y. S. Wu, H. K. Lee and S. F. Y. Li. A Fluorescence Detection Scheme for Capillary Electrophoresis of N-Methylcarbamates with On-Column Thermal Decomposition and Derivatization. Anal. Chem., 72, 1441-1447 (2000).
L. J. Jin, I. RodriguezI and S. F. Y. Li. Enantiomeric Separation of Amino Acids Derivatized with Fluoresceine Isothiocyanate Isomer I by Micellar Electrokinetic Chromatography Using b- And g-Cyclodextrins as Chiral Selectors. Electrophoresis, 20, 1538-1545 (1999).
X. Xiong and S. F. Y. Li. Design of Background Electrolytes for Indirect Photometric Detections Based on a Model of Sample Zone Absorption in Capillary Electrophoresis. JChromatography A, 835, 169-185 (1999).
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