photo Ph.D., 2003 in Royal Danish School of Pharmacy
M.Sc., 1998 in Technical University of Denmark


Contact Information

Experimental Therapeutics Centre, A*STAR
11, Biopolis Way, #03-10/11 The Helios
Singapore 138667
Tel: (+65)-6478 8767
DID: (+65)-6478 8767
Fax: (+65)-6478 8768
Email: apoulsen@etc.a-star.edu.sg



Research Interests

  • Drug Design
  • Drug Discovery
  • Computational Chemistry
  • Medicinal Chemistry
  • Cheminformatics

 

Representative Publications

Patent

  • SG10201508413Q
    "Compounds For Treatment of Cancer and Epigenetics"
    Klement Jihao Foo, Anders Poulsen, Thomas Hugo Keller, Si Si Liew, Cheng San
    Brian Chia and Melgious Jin Yan.
  • GB1513019.8
    "CYCLIC PEPTIDE SERINE PROTEASE INHIBITOR"
    Cheng San Brian Chia and Anders Poulsen.
  • WO/2015/187094 (PCT/SG2015/050132)
    "Phthalimide derivatives as modulators of WNT pathway"
    Wang Wei Ling, Ho See Yei, Jenefer Alam, Anders Poulsen and Jeyaraj Duraiswamy.
  • WO/2015/108490 (PCT/SG2015/050005)
    "Heteroaryl Alkyne Derivatives And Uses Thereof"
    Kassoum Nacro, Lohitha Rao Chennamaneni, Joseph Cherian and Anders Poulsen.
  • WO/2015/094118 (PCT/SG2014/000601)
    "Maleimide Derivatives as Modulators of WNT pathway"
    Jenefer Alam, Anders Poulsen, Ho See Yei, Wang Wei Ling and Jeyaraj Duraiswamy.
  • WO/2009/045174 (PCT/SG2008/000378)
    "2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K"
    Harish Kumar Mysore Nagaraj, Dizhong Chen, Anders Poulsen and Meredith
    Williams.
  • WO/2008/140419 (PCT/SG2008/000178)
    "PYRIDYL SUBSTITUTED PYRIMIDINE DERIVATIVES"
    Dizhong Chen, Cheng Hsia Angeline Lee, Harish Kumar Mysore Nagaraj, Anders
    Poulsen and Anthony Deodaunia William.
  • WO/2007/058628 (PCT/SG2006/000353)
    "HETEROALKYL LINKED PYRIMIDINE DERIVATIVES"
    Stéphanie Blanchard, Kantharaj Ethirajulu, Cheng Hsia Angeline Lee, Harish Kumar
    Mysore Nagaraj, Anders Poulsen, Eric, T. Sun, Yee Ling Evelyn Tan, Ee Ling Teo and
    Anthony Deodaunia William.
  • WO/2007/058627 (PCT/SG2006/000352)
    "OXYGEN LINKED PYRIMIDINE DERIVATIVES"
    Stéphanie Blanchard, Cheng Hsia Angeline Lee, Harish Kumar Mysore Nagaraj,
    Anders Poulsen, Eric, T. Sun, Yee Ling Evelyn Tan and Anthony Deodaunia William.
  • WO/2007/058626 (PCT/SG2006/000351)
    "INDAZOLE COMPOUNDS"
    Stéphanie Blanchard, Weiping Deng, Cheng Hsia Angeline Lee, Anders Poulsen, Ee
    Ling Teo, Noah P. Tu and Anthony Deodaunia William.
  • WO/2005/016884 (PCT/DK2004/000538)
    "CYCLOPROPYL DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS"
    Jan Kehle, Tore Hansen, Anders Poulsen, Berith Bjørnholm, Thomas Ruhland, Morten
    Bang Nørgaard, Søren Møller Nielsen.
  • WO/2003/051869 (PCT/DK2002/000858)
    "3,4-DIHYDRO-1H-ISOQUINOLOIN-2-YL-DERIVATIVES"
    Jan Kehler, Anders Poulsen, Berith Bjørnholm, Friedrich Kroll and Morten Bang
    Nørgaard.

 

Book Chapters

  • Macrocycles in Drug Discovery, RSC Books (2015) Chapter 5, p141-205
    Anders Poulsen, Anthony D. William and Brian W. Dymock
    "Designed Macrocyclic Kinase Inhibitors"
    DOI: 10.1039/9781782623113-00141

 

Journal Publications

  • Structure, 23 (2015) p2076-2086
    Ajaybabu V. Pobbati, Xiao Han, Alvin Wei Hung, Seetoh Weiguang, Nur Huda, Guo-
    Ying Chen, CongBao Kang Cheng San Brian Chia, Xuelian Luo, Wanjin Hong and
    Anders Poulsen.
    "Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential
    Cancer Therapeutic Strategy"
    DOI: 10.1016/j.str.2015.09.009
  • Drug Des. Dev. Ther., 9 (2015) p6389-6399
    Xiaoying Koh-Stenta, Joma Joy, Si Fang Wang, Perlyn Zekui Kwek, John Liang Kuan
    Wee, Kahfei Wan, Shovanlal Gayen, Angela Shuyi Chen, CongBao Kang, May Ann
    Lee, Anders Poulsen, Jeffrey Hill and Kassoum Nacro.
    "Identification of Covalent Active Site Inhibitors of Dengue Virus Protease"
    DOI: 10.2147/DDDT.S94207
  • J. Chem. Inf. Model., 55 (2015) p1435−1448
    Anders Poulsen, Soo Yei Ho, Weiling Wang, Jenefer Alam, Duraiswamy A. Jeyaraj,
    Ang Shi Hua, Eldwin Sum Wai Tan, Grace Ruiting Lin, Vivien Wei Wen Cheong,
    Zhiyuan Ke, May Ann Lee and Thomas H. Keller.
    "A pharmacophore model for Wnt/Porcupine inhibitors"
    DOI: 10.1021/acs.jcim.5b00159
  • J. Med. Chem., 58 (2015) p5889–5899
    Athisayamani Jeyaraj Duraiswamy, May Ann Lee, Babita Madan, Shi Hua Ang, Eldwin
    Tan Sum Wai, Wei Wen Vivien Cheong, Zhiyuan Ke, Vishal Pendharkar, Lijun Ding,
    Yun Shan Chew, Vithya Manoharan, Kanda Sangthongpitag, Jenefer Alam, Anders
    Poulsen, Soo Yei Ho, David M. Virshup and Thomas H. Keller.
    "Discovery and Optimization of a Porcupine Inhibitor"
    DOI: 10.1021/acs.jmedchem.5b00507
  • ChemPlusChem, 80 (2015) p1250-1254
    Guo-Ying Chen, Fui Mee Ng, Yih Wan Tan, Anders Poulsen, Weiguang Seetoh, Grace
    Lin, CongBao Kang, Siew Wen Then, Nur Huda Ahmad, Ying Lei Wong, Hui Qi Ng,
    Brian Chia, Qiu Ying Lau, Jeffrey Hill, Alvin W. Hung and Thomas H. Keller.
    "Application of Fragment-based Drug Discovery against DNA Gyrase B"
    DOI: 10.1002/cplu.201500197
  • mBIO, 6 (2015) e00253-15
    Wilfried Moreira, Grace Ngan, Jian Liang Low, Anders Poulsen, Brian Chia, Melgious
    Ang, Amelia Yap, Justina Fulwood, Umayal Lakshmanan, Jolander Lim,Audrey Ting,
    Horst Flotow, Jeffrey Hill,Ravikiran Raju, Eric Rubin and Thomas Dick.
    "A target mechanism-based whole cell screen identifies Bortezomib as an inhibitor of
    caseinolytic protease in mycobacteria"
    DOI: 10.1128/mBio.00253-15

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