PHOTO B.Sc. (Hons) Microbiology, 2004, National University of Singapore; Ph.D., 2007, National University of; Singapore

Contact Information

Defence Medical and Environmental
Research Institute (DMERI)
DSO National Laboratories
#12-01, 27 Medical Drive,
Singapore 117510.
Tel: (65) 6485-7214
Fax: (65) 6485-7226
Email: mahesh@dso.org.sg



Research Interests

We at DSO National Laboratories welcome applications from students who would like to work in areas of defence science and technology at DSO National Laboratories. Internship and scholarship opportunities are available for bright and talented undergraduate students (eg. SOAR - Sponsorship for Aspiring Researchers) as well as for awards for post-graduate training (eg. DSO PhD Research Award). For more information, visit www.dso.org.sg

The research program in my group is directed towards the development and exploitation of chemical tools to solve biological problems. We also develop platforms that accelerate genotyping, and study the genetics of complex disorders, including human diseases like hypertension, obesity and cardiovascular disorders.

There are four broad areas that we are interested in, namely:

1) Proteomics/ Functional Genomics

  • Novel strategies in developing small molecule, peptide and protein microarrays for high-throughput applications
  • Developing tools for large-scale proteomics
  • High-throughput enzyme screening systems
  • Kinase, protease and phosphatase profiling

2) Peptide and Protein Engineering

  • Solid phase peptide synthesis
  • Combinatorial chemistry
  • Ribosome/Phage display

3) High-Throughput Genotyping

  • Developing strategies to rapidly profile multiple single nucleotide polymorphisms (SNPs)
  • Developing genotyping platforms on microarrays and bead-arrays.

4) Human Disease Genetics

  • Studying polymorphisms that predispose individuals to hypertension, obesity and cardiovascular disorders
  • Investigating genetic causes of sudden cardiac deaths

Recent Highlights

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Figure 1. Uttamchandani, M. et al. J. Am. Chem. Soc. 2007, 129, 13110-13117.

 

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Figure 2. Uttamchandani, M.,* et al. Trends Biotechnol. 200927, 53-61.17.



Representative Publications

For complete list of publications click here

  • Uttamchandani, M., Lu C.H.S., Yao, S. Q. "High-Throughput Methodologies in Systematic Enzyme Profiling" Acc. Chem. Res. 2009. In press.

  • Uttamchandani, M.,* Neo, J.L., Ong, N. Z. B., Moochhala, S. "Applications of Microarrays in Pathogen Detection and Biodefence" Trends Biotechnol. 2009, 27, 53-61.

  • Uttamchandani, M.,* Yao, S. Q. "Peptide Microarrays: Next Generation Biochips for Detection, Diagnostics and High-Throughput Screening" Curr. Pharm. Des. 2008, 14, 2428-2438.

  • Uttamchandani M., Li, J., Sun, H., Yao, S. Q. "Activity-Based Protein Profiling: New Developments and Directions in Functional Proteomics" ChemBioChem. 2008, 9, 667-675.

  • Uttamchandani, M., Lee, W. L., Wang, J., Yao, S. Q. "Quantitative Inhibitor Fingerprinting of Metalloproteases using Small Molecule Microarrays" J. Am. Chem. Soc. 2007, 129, 13110-13117.

  • Uttamchandani, M., Wang, J., Li, J., Hu, M., Sun, H., Chen, K. Y.-T., Liu, K., Yao, S. Q. "Inhibitor Fingerprinting of Matrix Metalloproteases using a Combinatorial Peptide Hydroxamate Library" J. Am. Chem. Soc. 2007, 129, 7848-7858.

  • Uttamchandani, M., Liu, K., Panicker, R. C., Yao, S. Q. "Activity-Based Fingerprinting and Inhibitor Discovery of Cysteine Proteases in a Microarray" Chem. Comm. 2007, 1518-1520.

  • Uttamchandani, M., Wang, J., Yao, S.Q. "Protein and Small Molecule Microarrays: Powerful Tools for High-Throughput Proteomics" Mol. BioSyst.2006, 2, 58-68.

  • Uttamchandani, M., Huang, X., Chen, G. Y. J., Yao, S. Q. "Nanodroplet Profiling of Enzymatic Activity on Microarrays" Bioorg. Med. Chem. Lett. 2005, 15, 2135-2139.  

  • Uttamchandani, M., Walsh, D. P., Yao, S. Q., Chang, Y. T. "Small Molecule Microarrays – Recent Advances and Applications" Curr. Opin. Chem. Biol. 2005,9, 4-13.