Assistant Professor Ge Shaozhong

photo of Dr Ge Shaozhong

Group Website

Postdoc, 2010-2014, and University of California at Berkeley and University of Illinois at Urbana-Champaign; Ph.D, 2009, University of Groningen; M. Sci., 2004, Åbo Akademi University; B.Sc., 2002, University of Science and Technology of China.


Contact Information

Department of Chemistry, NUS
3 Science Drive 3
Singapore 117543

Office: MD1-17-03F
Tel: (65)-6516 7761
Fax: (65)-6779-1691
Email: chmgsh@nus.edu.sg

 

POSTDOC AND PH.D POSITION OPENINGS

We have multiple openings available on Ph.D. and postdoc levels. Talented and self-motivated chemists with strong background and experience in organometallic and organic synthesis are encouraged to apply for the postdoc openings. Students who are interested in synthetic organometallic and organic chemistry are welcome to apply for the Ph.D. openings. For application, please send an electronic copy of CV, research summary, and contact information of references to chmgsh@nus.edu.sg.

 

Research Interests

Organometallic Chemistry, Organic Chemistry, Homogeneous Catalysis, Asymmetric Catalysis

The GE Research Group at NUS aims to discover and understand transition-metal-catalyzed reactions of organic molecules. We will focus on the development of practical first-row metal-catalyzed reactions that address problems encountered in the synthesis of complex organic molecules and drug discovery. Our approaches to reaction discovery will involve identification and synthesis of potential organometallic intermediates, the systematic study of their reactivity, and the detailed kinetic and mechanistic study. Ultimately, our goal is to provide synthetic organic chemists with new catalysts and new organic reactions of practical applications in chemical and pharmaceutical industry.

Our focus on both fundamental and practical aspects of our reaction discovery provides an opportunity for students in my group to get trained and expertized in various aspects of organometallic chemistry, synthetic organic chemistry, and physical organic chemistry.


Representative Publications

  • Ge, S.; Arlow, S. I.; Mormino, G.; Hartwig, J. F. “Pd-Catalyzed a-Arylation of Trimethylsilyl Enolates of a,a-Difluoroacetamides” J. Am. Chem. Soc. 2014, 136, 14401-14404. Highlighted by C&EN (2014, 92, P25).

  • Ge, S.; Chaladaj, W.; Hartwig, J. F. “Pd-Catalyzed a-Arylation of a,a-Difluoroketones with Aryl Bromides and Chlorides. A Route to Difluoromethylarenes” J. Am. Chem. Soc. 2014, 136, 4149-4152. Highlighted by C&EN (2014, 92, P25).
  • Ge, S.; Green, R. A.; Hartwig, J. F. “Controlling First-Row Metal Catalysts: Amination of Aryl and Heteroaryl Chlorides and Bromides with Primary Aliphatic Amines Catalyzed by a BINAP-Ligated Single-Component Ni(0) Complex” J. Am. Chem. Soc. 2014, 136, 1617-1627.
  • Ge, S.; Hartwig, J. F. “A Highly Reactive Single-Component Nickel Precursor for Suzuki-Miyaura Cross-Coupling of Heteroaryl Halides with Heteroarylboronic Acids” Angew. Chem. Int. Ed. 2012, 51, 12837-12841. Highlighted by Synfacts (2013, 9, 0143).
  • Ge, S.; Hartwig, J. F. “Nickel-Catalyzed Asymmetric a-Arylation and Heteroarylation of Ketones with Chloroarenes: Effect of Halide on Selectivity, Oxidation State, and Room-Temperature Reactions” J. Am. Chem. Soc. 2011, 133, 16330-16333. Highlighted by Synfacts (2012, 8, 0055).
  • Ge, S.; Meetsma, A.; Hessen, B. “Highly Efficient Hydrosilylation of Alkenes by Organoyttrium Catalysts with Sterically Demanding Amidinate and Guanidinate Ligands” Organometallics 2008, 27, 3131-3135.
  • Ge, S.; Bambirra, S.; Meetsma, A.; Hessen, B “The 6-amino-6-methyl-1,4-diazepine group as an ancillary ligand framework for neutral and cationic scandium and yttrium alkyls” Chem. Commun. (Cambridge, United Kingdom) 2006, 31, 3320-3322.
  • Hartwig, J. F.; Ge, S.; Chaladaj, W. “Metal-Catalyzed Coupling of Aryl and Vinyl Halides with alfa, alfa-Difluorocarbonyl Compounds” PCT Int. Appl. (2014), WO201465861 A1 20141009.
  • Andel, O. S.; Penninkangas, A.; Ge, S.; Paavola, S. “Siloxy substituted metallocene catalysts” Eur. Pat. Appl. (2007), 34pp. EP 1752462 A1 20070214.
  • Andel, O. S.; Penninkangas, A.; Ge, S. “Transition-metal metallocenes with mono- or bicyclic multi-siloxy-substituted cyclopentadienyl groups, their preparation and use as polymerization catalysts” Eur. Pat. Appl. (2006), 20pp. EP 1640378 A1 20060329.