Assistant Professor KOH Ming Joo

(President's Assistant Professor)




Ph.D. and Postdoc in Organic Chemistry, Boston College, MA, 2018; B.Sc. (Hons) First Class in Chemistry & Biological Chemistry, Nanyang Technological University, 2012.

Contact Information

Office: MD1-17-03C
Tel: (65)-6601-7489 | Fax: (65)-6779-1691
Email: chmkmj@nus.edu.sg | Personal webpage


 

ORCID: 0000-0002-2534-4921
ResearcherID: M-6641-2018
Google Scholar: https://scholar.google.com.sg/citations?user=f1n6bRcAAAAJ&hl=en

 

Recognition and Achievements

  • NUS Inauguration Grant, NUS, 2019
  • President's Assistant Professorship, NUS, 2018
  • Bristol-Myers Squibb Graduate Fellowship in Synthetic Organic Chemistry, 2016-2017
  • LaMattina Family Graduate Fellowship in Chemical Synthesis, 2016
  • Best Poster Award, ISOM XXI, 2015

 

Research Interests

The key objective of our program is to develop sustainable and enabling catalytic solutions that address critical and unresolved problems in chemical synthesis. Our research approach will leverage creative, direct and unprecedented disconnections of complex target molecules to fuel our efforts in devising practical stereoselective methods that utilize abundant, biocompatible and inexpensive catalysts. Insights gained from mechanistic studies will aid us in designing new catalyst systems that promote transformations to facilitate economically and environmentally viable preparation of important compounds for the chemical, pharmaceutical and polymer industries. Current topics of interest include homogeneous base metal catalysis, heterogeneous single-atom catalysis and radical chemistry. We cordially welcome collaborations in all areas of research including total synthesis, computational studies, chemical biology and materials science.

 

Research Highlight

Tao, Y.; Chen, X.; Rao, W.; Koh, M. J., Broadly Applicable Directed Catalytic Reductive Difunctionalization of Alkenyl Carbonyl Compounds. Chem 2020, DOI: 10.1016/j.chempr.2019.12.026.

 

Representative Publications  

  • Chen, Z.; Liu, C.; Liu, J.; Li, J.; Xi, S.; Chi, X.; Xu, H.; Park, I.-H.; Peng, X.; Li, X.; Yu, W.; Liu, X.; Zhong, L.; Leng, K.; Huang, W.; Koh, M. J.; Loh, K. P., Cobalt Single-Atom-Intercalated Molybdenum Disulfide for Sulfide Oxidation with Exceptional Chemoselectivity. Adv. Mater. 2019, 1906437.
  • Liu, C.; Chen, Z.; Yan, H.; Yam, K. M.; Gao, J.; Du, Y.; Xi, S.; Li, J.; Zhao, X.; Xu, H.; Li, X.; Fu, W.; Leng, K.; Xie, K.; Pennycook, S. J.; Liu, B.; Zhang, C.; Koh, M. J.; Loh, K. P., Expedient Synthesis of E-Hydrazone Esters and 1H-Indazole Scaffolds through Heterogeneous Single-Atom Platinum Catalysis. Sci. Adv. 2019, 5, eaay1537.
  • Mu, Y.; Nguyen, T. T.; Koh, M. J.; Schrock, R. R.; Hoveyda, A. H., E- and Z-, Di-,and Trisubstituted Alkenyl Nitriles through Catalytic Cross-Metathesis. Nat. Chem. 2019, 11, 478-487.
  • Nguyen, T. T.; Koh, M. J.; Mann, T. J.; Schrock, R. R.; Hoveyda, A. H., Synthesis of E- or Z-Trisubstituted Alkenes by Catalytic Cross-Metathesis. Nature 2017552, 347-354.
  • Koh, M. J.; Nguyen, T. T.; Lam, J. K.; Torker, S.; Hyvl, J.; Schrock, R. R.; Hoveyda, A. H., Molybdenum Chloride Catalysts for Z-Selective Olefin Metathesis Reactions. Nature 2017542, 80-85.
  • Shen, X.; Nguyen, T. T.; Koh, M. J.; Xu, D.; Speed, A.W. H.; Schrock, R. R.; Hoveyda, A. H., Kinetically E-Selective Macrocyclic Ring-Closing Metathesis. Nature 2017541, 380.
  • Nguyen, T. T.; Koh, M. J.; Shen, X.; Romiti, F.; Schrock, R. R.; Hoveyda, A. H., Kinetically Controlled E-Selective Catalytic Olefin Metathesis. Science 2016352, 569-575.
  • Koh, M. J.; Nguyen, T. T.; Zhang, H.; Schrock, R. R.; Hoveyda, A. H., Direct Synthesis of Z-Alkenyl Halides by Catalytic Cross-Metathesis. Nature 2016531, 459-465.
  • Koh, M. J.; Khan, R. K. M.; Torker, S.; Yu, M.; Mikus, M. S.; Hoveyda, A. H., High-Value Alcohols and Higher-Oxidation-State Compounds by Catalytic Z-Selective Cross-Metathesis. Nature 2015517, 181-186.