Professor LEE Hian Kee

B.Sc., University of Canterbury, 1978; Ph.D., University of Canterbury, 1982; Special Volunteer, National Institutes of Health, Bethesda, USA, 1991/1992

Contact Information

Office: S5-02-12
Tel: (65)-6516-2995 | Fax: (65)-6779-1691


ORCID: 0000-0002-5664-9509

ResearcherID: B-3983-2018


Recognition and Achievements

  • NUS Provost’s Term Chair Professor, 2011-2014
  • Editor, Journal of Chromatography A, 2010 - current; Editorial Board, Journal of Chromatography A, 2004 - 2010
  • Member, Editorial Boards, Chemical Data Collections, 2015 - current; Talanta, 2017 - 2019
  • Editor, Analytica Chimica Acta, 2005 - 2011; Editorial Advisor, Analytica Chimica Acta, 2003 - 2005
  • Member, Advisory Board, Analytical Sciences, 2004 - current
  • Member, Editorial Advisory Boards, LC·GC Asia Pacific, 2006 - current; LC·GC Europe, 2008 - current
  • Member, International Editorial Advisory Board, Journal of the Chinese Chemical Society, 2011 - 2015
  • Member, International Advisory Board, Analyst, 1997 - 2008
  • NUS Outstanding Researcher Award, 2006
  • NUS Faculty of Science Outstanding Scientist Award, 2009
  • Federation of Asian Chemical Societies Foundation Award, 2009
  • Hyflux-Singapore National Institute of Chemistry Award in Environmental Chemistry, 2013
  • The Analytical Scientist Power List: “100 Most Influential People in the Analytical Sciences,” 2013, 2015
  • Fellow, Royal Society of Chemistry
  • Fellow, Singapore National Academy of Science
  • Fellow, Academy of Sciences Malaysia


Research Interests

  • Our main interest lies in the development and applications of miniaturized, solvent-minimized sample preparation procedures, in combination with chromatographic techniques. A primary objective is to apply these methods to environmental analysis of contaminants of emerging, etc.
  • We also have an interest to develop completely integrative, automated analytical platforms for water quality monitoring applications


Research Highlight

Ref: Majedi, S. M.; Lee, H. K. Microextraction and Solventless Techniques, in The Application of Green Solvents in Separation Processes (Pena-Pereira, F.; Tobiszewski, M., editors), Elsevier, 2017, pp. 415-450 (invited).

This is an invited book chapter that covers solvent minimized and solventless extraction procedures, and reviews their principles, advantages, limitations, and recent applications and trends.


Teaching Contributions

  • CM5152 Water Chemistry and Environment
  • CM5244 Topics in Environmental Chemistry


Representative Publications  

  • Liew, C. S. M.; Li, X.; Lee, H. K. Miniscale Liquid-liquid Extraction Coupled with Full Evaporation Dynamic Headspace Extraction for the Gas Chromatography/Mass Spectrometric Analysis of Polycyclic Aromatic Hydrocarbons with 4000- to 14000-Fold Enrichment. Anal. Chem. 2016, 88, 9095-9102.
  • Guo, L.; binte Nawi, N.; Lee, H. K. Fully Automated Headspace Bubble-In-Drop Microextraction. Anal. Chem. 2016, 88, 8409-8414.
  • Tang, S.; Zhang, H.; Lee, H. K. Advances in Sample Extraction. Anal. Chem. 2016, 88, 228-249 (invited).
  • Guo, L.; Chia, S.H.; Lee, H. K., Automated Agitation-Assisted Demulsification Dispersive Liquid-Liquid Microextraction. Anal. Chem. 2016, 88, 2548-2552.
  • Tang, S.; Lee, H. K. Application of Dissolvable Layered Double Hydroxides as Sorbent in Dispersive Solid-Phase Extraction and Extraction by Co-Precipitation for the Determination of Aromatic Acid Anions. Anal. Chem. 2013, 85, 7426-7433.
  • Lee, J.; Lee, H. K. Fully Automated Dynamic In-Syringe Liquid-Phase Microextraction and On-Column Derivatization of Carbamate Pesticides with Gas Chromatography/Mass Spectrometric Analysis. Anal. Chem. 2011, 83, 6856-6861.
  • Shen, G.; Lee, H. K. Hollow Fiber-Protected Liquid-Phase Microextraction of Triazine Herbicides. Anal. Chem. 2002, 74, 648-654.
  • He, Y.; Lee, H. K. Liquid-Phase Microextraction in a Single Drop of Organic Solvent by Using a Conventional Microsyringe. Anal. Chem. 1997, 69, 4634-4640.