Professor LI Fong Yau, Sam

B.Sc., 1981, Imperial College; Ph.D., 1984, Imperial College; D.Sc., 1999, University of London

Contact Information

Department of Chemistry, NUS 
3 Science Drive 3 
Singapore 117543 
Office: S5-02-03
Tel: (65)-6516-2681
Fax: (65)-6779-1691
Email: chmlifys@nus.edu.sg



Research Interests

Analytical Chemistry

  • Capillary electrophoresis and chromatographic techniques: New analytical methods based on capillary electrophoresis have been developed. The methods have been applied in environmental, pharmaceutical, biochemical and clinical analyses. Supercritical fluid extraction has been used to extract compounds from natural products and environmental samples. Methods have been developed for systematic optimization of high performance liquid chromatographic separations.
  • Atomic force microscopy and related scanning probe techniques: Nanoscale analysis and device fabrication by scanning probe techniques have been studied. On-going research projects include development of in-situ monitoring techniques for semiconductor manufacturing processes by atomic force microscopy, and study of lubricants on hard disk by atomic force microscopy and frictional force microscopy.
  • Sensor technology: Quartz Crystal microbalance and surface acoustic wave devices are used for chemical sensing, biosensing, process control and environmental monitoring. Selective coatings are developed for detection of various chemicals and biochemicals, such as toxic vapors, environmental pollutants in water samples, proteins and antigens.



Representative Publications

  • Liu, F.; Gan, P. P.; Wu, H. N.; Woo, W. S.; Ong, E. S.; Li, S. F. Y., A combination of metabolomics and metallomics studies of urine and serum from hypercholesterolaemic rats after berberine injection. Analytical and Bioanalytical Chemistry 2012, 403 (3), 847-856
  • Gan, P. P.; Ng, S. H.; Huang, Y.; Li, S. F. Y., Green synthesis of gold nanoparticles using palm oil mill effluent (POME): A low-cost and eco-friendly viable approach. Bioresource Technology 2012, 113, 132-135
  • Fang, G.; Lau, H. F.; Law, W. S.; Li, S. F. Y., Systematic optimisation of coupled microwave-assisted extraction-solid phase extraction for the determination of pesticides in infant milk formula via LC-MS/MS. Food Chemistry 2012, 134 (4), 2473-2480
  • Lu, M.; Kharkwal, S.; Ng, H. Y.; Li, S. F. Y., Carbon nanotube supported MnO2 catalysts for oxygen reduction reaction and their applications in microbial fuel cells. Biosensors & Bioelectronics 2011, 26 (12), 4728-4732
  • Lau, H. F.; Quek, N. M.; Law, W. S.; Zhao, J. H.; Hauser, P. C.; Li, S. F. Y., Optimization of separation of heavy metals by capillary electrophoresis with contactless conductivity detection. Electrophoresis 2011, 32 (10), 1190-1194
  • Birungi, G.; Li, S. F. Y., Investigation of the effect of exposure to non cytotoxic amounts of microcystins. Metabolomics 2011, 7 (4), 485-499
  • Zuo, X. B.; Wu, H. A.; Toh, J.; Li, S. F. Y., Mechanism of mercury detection based on interaction of single-strand DNA and hybridized DNA with gold nanoparticles. Talanta 2010, 82 (5), 1642-1646
  • Tok, J.; Lai, J.; Leung, T.; Li, S. F. Y., Molecular aptamer beacon for myotonic dystrophy kinase-related Cdc42-binding kinase alpha. Talanta 2010, 81 (1-2), 732-736
  • Tok, J.; Lai, J.; Leung, T.; Li, S. F. Y., Selection of aptamers for signal transduction proteins by capillary electrophoresis. Electrophoresis 2010, 31 (12), 2055-2062
  • Birungi, G.; Chen, S. M.; Loy, B. P.; Ng, M. L.; Li, S. F. Y., Metabolomics Approach for Investigation of Effects of Dengue Virus Infection Using the EA hy926 Cell Line. Journal of Proteome Research 2010, 9 (12), 6523-6534
  • Liu, F.; Wan, S. Y.; Jiang, Z. J.; Li, S. F. Y.; Ong, E. S.; Osorio, J. C. C., Determination of pyrrolizidine alkaloids in comfrey by liquid chromatography-electrospray ionization mass spectrometry. Talanta 2009, 80 (2), 916-923
  • Birungi, G.; Li, S. F. Y., Determination of cyanobacterial cyclic peptide hepatotoxins in drinking water using CE. Electrophoresis 2009, 30 (15), 2737-2742
  • A. P. Fang, H. Ng, X. D. Su and S. F. Y. Li. Soft-Lithography-Mediated Submicrometer Patterning of Self-Assembled Monolayer of Hemoglobin on ITO Surfaces. Langmuir16, 5221-5226 (2000). 
  • Y. S. Wu, H. K. Lee and S. F. Y. Li. Simultaneous Chiral Separation of Triadimefon and Triadimenol by Sulfated b-Cyclodextrin-Mediated Capillary Electrophoresis. Electrophoresis21, 1611-1619 (2000).
  • Y. S. Wu, H. K. Lee and S. F. Y. Li. A Fluorescence Detection Scheme for Capillary Electrophoresis of N-Methylcarbamates with On-Column Thermal Decomposition and Derivatization. Anal. Chem.72, 1441-1447 (2000). 
  • L. J. Jin, I. RodriguezI and S. F. Y. Li. Enantiomeric Separation of Amino Acids Derivatized with Fluoresceine Isothiocyanate Isomer I by Micellar Electrokinetic Chromatography Using b- And g-Cyclodextrins as Chiral Selectors. Electrophoresis20, 1538-1545 (1999).
  • X. Xiong and S. F. Y. Li. Design of Background Electrolytes for Indirect Photometric Detections Based on a Model of Sample Zone Absorption in Capillary Electrophoresis. JChromatography A835, 169-185 (1999).