Professor YAO Shao Qin

B.Sc., Ohio State University (USA); PhD, Purdue University (USA); Postdoctoral, University of California Berkeley/ Scripps Research Institute (USA).

Contact Information

Office: S5-03-05
Tel: (65)-6516-2669 | Fax: (65)-6779-1691
Email: | Personal webpage


ORCID: 0000-0003-4715-769X
ResearcherID: B-8825-2008   


Recognition and Achievements

  • Member of the International Scientific Advisory Board, Angewandte Chemie,
  • Dean’s Chair Professor, National University of Singapore, 2009-2012.
  • ASAIHL-Scopus Young Scientist Award, International, 2008
  • Outstanding Scientist Award, Faculty of Science, National University of Singapore, Singapaore, 2007
  • Mr & Mrs Sun Chan Memorial Award, International, 2006
  • Young Research Award, National University of Singapore, 2005
  • Young Investigator Award, A*STAR Singapore, 2002


Research Interests

“Catalomics” - We are interested in developing powerful strategies in Chemical Biology and Chemical Proteomics that enable organism-wide, high-throughput studies of enzymes. Specific foci are:

  •  Chemical Biology
  •  Medicinal Chemistry


Research Highlight

Ref. : Ge, J.; Zhang, C.-W.; Ng, X. W.; Peng, B.; Pan, S.; Du, S. Wang, D.; Li, L.; Lim, K.-L.; Wohland, T.; Yao, S. Q. A Suite of Puromycin Analogs Capable of Multiplexed Imaging and Profiling of Protein Synthesis and Dynamics in Live Cells and Neurons. Angew. Chem. Int. Ed. 2016, 55, 4933-4937.  


Representative Publications   

  • Yu, C.; Qian, L.; Ge, J.; Fu, J.; Yuan, P.; Yao, S. Q. Cell-Penetrating Poly(disulfide)-Assisted Intracellular Delivery of Mesoporous Silica Nanoparticles for Inhibition of miR-21 Functions and Detection of Subsequent Therapeutic Effects. Angew. Chem. Int. Ed.  2016, 55, 9272-9276.
  • Li, Z.; Qian, L.; Li, L.; Bernhammer, J. C.; Huynh, H. V.; Lee, J.-S.; Yao, S. Q. Tetrazole Photoclick Chemistry: Reinvestigating Its Suitability as a Bioorthogonal Reaction and Potential Applications. Angew. Chem. Int. Ed. 2016, 55, 2002-2006.
  • Fu, J.; Yu, C.; Li, L.; Yao, S.Q. Intracellular Delivery of Functional Proteins and Native Drugs by Cell-Penetrating Poly(disulfide)s. J. Am. Chem. Soc.2015, 137, 12153-12160.
  • Yu, C. M.; Qian, L. H.; Uttamchandani, M.; Li, L.; Yao, S. Q. Single-Vehicular Delivery of Antagomir and Small Molecules to Inhibit miR-122 Function in Hepatocellular Carcinoma Cells by using "Smart" Mesoporous Silica Nanoparticles. Angew. Chem. Int. Ed. 2015, 54, 10574-10578.
  • Li, L.; Zhang, C. W.; Ge, J. Y.; Qian, L. H.; Chai, B. H.; Zhu, Q.; Lee, J. S.; Lim, K. L.; Yao, S. Q. A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson's Disease. Angew. Chem. Int. Ed. 2015, 54, 10821-10825.
  • Na, Z. K.; Peng, B.; Ng, S. K.; Pan, S. J.; Lee, J. S.; Shen, H. M.; Yao, S. Q. A Small-Molecule Protein-Protein Interaction Inhibitor of PARP1 that Targets Its BRCT Domain. Angew. Chem. Int. Ed. 2015, 54, 2515-2519.
  • Li, L.; Zhang, C. W.; Chen, G. Y. J.; Zhu, B. W.; Chai, C.; Xu, Q. H.; Tan, E. K.; Zhu, Q.; Lim, K. L.; Yao, S. Q. A Sensitive Two-Photon Probe to Selectively Detect Monoamine Oxidase B Activity in Parkinson's Disease Models. Nat. Commun. 2014, 5, 10.