Associate Professor ZHAO Yu

(Assistant Dean - Graduate Studies and Safety)

B.S., 2002, Peking University; Ph.D., 2008, Boston College; Postdoctoral, 2008-2011, Massachusetts Institute of Technology

Contact Information

Office: S5-03-09
Tel: (65)-6516-7964 | Fax: (65)-6779-1691
Email: | Personal webpage


ORCID: 0000-0002-2944-1315
ResearcherID: J-1712-2014


Recognition and Achievements

  • Outstanding Chemist Award, Department of Chemistry, NUS, 2017
  • Thieme Chemistry Journal Award, 2016
  • Young Scientist Award, Faculty of Science, NUS, 2015
  • Young Chemist Award, Department of Chemistry, NUS, 2015


Research Interests

To develop simple (asymmetric) catalytic systems to address key problems in chemistry.


Research Highlight

Reported the first enantioselective synthesis of ten-membered heterocycles:


Teaching Contributions

  • CM3221 Organic Synthesis: The Disconnection Approach
  • CM4228 Catalysis


Representative Publications   

  • Lu, S. et al. Transition Metal-Free Decarboxylative Propargylic Substitution/Cascade Cyclization with Azolium Enolates or Acyl Anions. Angew. Chem. Int. Ed2018, 57, 5714.
  • Wang, Y.-N. et al. Pd-Catalyzed Enantioselective [6+4] Cycloaddition of Vinyl Oxetanes with Azadienes to Access Ten-Membered Heterocycles. Angew. Chem. Int. Ed2018, 57, 1596.
  • Rong, Z. Q. et al. Nine-Membered Benzofuran-Fused Heterocycles: Enantioselective Synthesis and Rearrangement via Transannular Bond Formation. J. Am. Chem. Soc. 2017139, 15304.
  • Lim, C. S. et al. Enantioselective Synthesis of Tetrahydroquinolines Using Borrowing Hydrogen. Angew. Chem. Int. Ed201756, 7176 (VIP article).
  • Liu, T.-L. et al. Rhodium-Catalyzed Enantioselective Isomerization of Secondary Allylic Alcohols. J. Am. Chem. Soc. 2017139, 3643.
  • Yang, L.-C. et al. Construction of Nine-Membered Heterocycles through Palladium-Catalyzed Formal [5 + 4] Cycloaddition. Angew. Chem. Int. Ed201756, 2927.
  • Huang, Y. et al. Cobalt-Catalyzed Enantioselective Vinylation of Activated Ketones and Imines. J. Am. Chem. Soc. 2016138, 6571.
  • Rong, Z. Q. et al. Dynamic Kinetic Asymmetric Amination of Alcohols: From A Mixture of Four Isomers to Diastereo- and Enantiopure a-Branched Amines. J. Am. Chem. Soc. 2015137, 4944.
  • Zhang, Y. et al. Catalytic Enantioselective Amination of Alcohols by the Use of Borrowing Hydrogen Methodology: Cooperative Catalysis by Iridium and a Chiral Phosphoric Acid. Angew. Chem. Int. Ed2014, 53, 1399.